ความเชี่ยวชาญ

อยู่ระหว่างเพิ่มเติมข้อมูล

ผลงานดีเด่นและรางวัล

• Young Investigator Award by the Committee of the 29th Asian Pacific Association for the Study of the Liver (APASL) 2020 in Bali, Indonesia
• Young Investigator Bursary award [EASL-AASLD 2019] London, UK
• Travel Award for Outstanding Young Investigator [Asian Pacific Digestive Week 2016 (APDW 2016) Kobe, Japan, 2016]
• Young Investigator Award [25^th Asian Pacific Association for the Study of the Liver (APASL), Tokyo, Japan, 2016]
• Outstanding Graduate Student Awards in doctoral degree, Chulalongkorn University, 2018
• Outstanding Graduate Student Awards in master’s degree, Chulalongkorn University, 2014

บทความวิจัยในวารสาร

1. Kunadirek P, Pinjaroen N, Nookaew I, Tangkijvanich P, Chuaypen N. Transcriptomic Analyses Reveal Long Non-Coding RNA in Peripheral Blood Mononuclear Cells as a Novel Biomarker for Diagnosis and Prognosis of Hepatocellular Carcinoma. International Journal of Molecular Sciences. 2022 Jan;23(14):7882.
2. Jinato T, Chayanupatkul M, Dissayabutra T, Chutaputti A, Tangkijvanich P, Chuaypen N. Litchi-Derived Polyphenol Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blinded, Placebo-Controlled Study. Nutrients. 2022 Jan;14(14):2921.
3. Chayanupatkul M, Somanawat K, Chuaypen N, Klaikeaw N, Wanpiyarat N, Siriviriyakul P, Tumwasorn S, Werawatganon D. Probiotics and their beneficial effects on alcohol-induced liver injury in a rat model: the role of fecal microbiota. BMC Complement Med Ther. 2022 Jun 22;22(1):168. doi: 10.1186/s12906-022-03643-9. PMID: 35733194.
4. Choodej S, Koopklang K, Raksat A, Chuaypen N, Pudhom K. Bioactive xanthones, benzophenones and biphenyls from mangosteen root with potential anti-migration against hepatocellular carcinoma cells. Sci Rep. 2022 May 21;12(1):8605. doi: 10.1038/s41598-022-12507-8. PMID: 35597781
5. Chuaypen N, Siripongsakun S, Hiranrat P, Tanpowpong N, Avihingsanon A, Tangkijvanich P. Improvement of liver fibrosis, but not steatosis, after HCV eradication as assessment by MR-based imaging: Role of metabolic derangement and host genetic variants. PLoS One. 2022. doi: 10.1371/journal.pone.0269641.
6. Oekchuae S, Sirirak J, Charoensuksai P, Wongprayoon P, Chuaypen N, Boonsombat J, Ruchirawat S, Tangkijvanich P, Suksamrarn A, Limpachayaporn P. The Design and Synthesis of a New Series of 1,2,3-Triazole-Cored Structures Tethering Aryl Urea and Their Highly Selective Cytotoxicity toward HepG2. Pharmaceuticals (Basel). 2022 Apr 20;15(5):504. doi: 10.3390/ph15050504. PMID: 35631331.
7. Chuaypen N, Khlaiphuengsin A, Prasoppokakorn T, Susantitaphong P, Prasithsirikul W, Avihingsanon A, Tangkijvanich P, Praditpornsilpa K. Prevalence and genotype distribution of hepatitis C virus within hemodialysis units in Thailand: role of HCV core antigen in the assessment of viremia. BMC Infect Dis. 2022 Jan 22;22(1):79. doi: 10.1186/s12879-022-07074-2.
8. Srisomwat C, Yakoh A, Avihingsanon A, Chuaypen N, Tangkijvanich P, Vilaivan T, Chailapakul O. An alternative label-free DNA sensor based on the alternating-current electroluminescent device for simultaneous detection of human immunodeficiency virus and hepatitis C co-infection. Biosensors and Bioelectronics. 2022 Jan 15;196:113719.
9. Hayashi S, Isogawa M, Kawashima K, Ito K, Chuaypen N, Morine Y, Shimada M, Higashi-Kuwata N, Watanabe T, Tangkijvanich P, Mitsuya H, Tanaka Y. Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application. Sci Rep. 2022 Feb 8;12(1):2133. doi: 10.1038/s41598-022-05882-9. PMID: 35136096.
10. Boonkaew S, Yakoh A, Chuaypen N, Tangkijvanich P, Rengpipat S, Siangproh W, Chailapakul O. An automated fast-flow/delayed paper-based platform for the simultaneous electrochemical detection of hepatitis B virus and hepatitis C virus core antigen. Biosens Bioelectron. 2021 Dec 1;193:113543. doi: 10.1016/j.bios.2021.113543. Epub 2021 Aug 5. PMID: 34416431.
11. Chuaypen N, Limothai U, Kunadirek P, Kaewsapsak P, Kueanjinda P, Srisawat N, Tangkijvanich P. Identification and validation of circulating miRNAs as potential new biomarkers for severe liver disease in patients with leptospirosis. PLoS One. 2021 Sep 27;16(9):e0257805. doi: 10.1371/journal.pone.0257805. PMID: 34570814.
12. Teengam P, Nisab N, Chuaypen N, Tangkijvanich P, Vilaivan T, Chailapakul O. Fluorescent paper-based DNA sensor using pyrrolidinyl peptide nucleic acids for Hepatitis C virus detection. Biosensors and Bioelectronics. 2021 May 29:113381.
13. Chamsuwan S, Angkanaporn K, Dissayabutra T, Chuaypen N, Buranakarl C. The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs. J Vet Intern Med. 2021 Sep;35(5):2263-2270. doi: 10.1111/jvim.16225. Epub 2021 Jul 28. PMID: 34322901.
14. Patarat R, Riku S, Kunadirek P, Chuaypen N, Tangkijvanich P, Mutirangura A, Puttipanyalears C. The expression of FLNA and CLU in PBMCs as a novel screening marker for hepatocellular carcinoma. Sci Rep. 2021 Jul 21;11(1):14838. doi: 10.1038/s41598-021-94330-1. PMID: 34290294; PMCID: PMC8295309.
15. Koopklang K, Choodej S, Chuaypen N, Pudhom K. Xanthones from Garcinia mangostana inhibit the proliferation and migration of hepatocellular carcinoma cells. The Journal of Chulabhorn Royal Academy. 2021 Jan 15;3(1):40-8.
16. Chuaypen N, Chittmittrapap S, Avihingsanon A, Siripongsakun S, Wongpiyabovorn J, Tanpowpong N, Tanaka Y, Tangkijvanich P. Liver fibrosis improvement assessed by magnetic resonance elastography and Mac‐2‐binding protein glycosylation isomer in patients with hepatitis C virus infection receiving direct‐acting antivirals. Hepatology Research. 2021 May;51(5):528-37.
17. Matsui T, Hamada-Tsutsumi S, Naito Y, Nojima M, Iio E, Tamori A, Kubo S, Ide T, Kondo Y, Eguchi Y, Komori A, Morine Y, Shimada M, Utsunomiya T, Shirabe K, Kimura K, Hiasa Y, Chuaypen N, Tangkijvanich P, Naiki-Ito A, Takahashi S, Ochiya T, Tanaka Y. Identification of microRNA‐96‐5p as a postoperative, prognostic microRNA predictor in non‐viral hepatocellular carcinoma. Hepatology Research. 2021 May 26.
18. Kunadirek P, Ariyachet C, Sriphoosanaphan S, Pinjaroen N, Sirichindakul P, Nookaew I, Chuaypen N, Tangkijvanich P. Identification of BHLHE40 expression in peripheral blood mononuclear cells as a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma. Scientific reports. 2021 May 27;11(1):1-2.
19. Kunadirek P, Chuaypen N, Jenjaroenpun P, Wongsurawat T, Pinjaroen N, Sirichindakul P, Nookaew I, Tangkijvanich P. Cell-Free DNA Analysis by Whole-Exome Sequencing for Hepatocellular Carcinoma: A Pilot Study in Thailand. Cancers. 2021 Jan;13(9):2229.
20. Chuaypen N, Jinato T, Avihingsanon A, Chirapongsathorn S, Cheevadhanarak S, Nookaew I, Tanaka Y, Tangkijvanich P. Improvement of Gut Diversity and Composition after Direct-Acting Antivirals in HCV-Infected Patients with or without HIV Coinfection. J Infect Dis. 2021 Feb 17:jiab094. doi: 10.1093/infdis/jiab094. Epub ahead of print. PMID: 33598686.
21. Palakhachane S, Ketkaew Y, Chuaypen N, Sirirak J, Boonsombat J, Ruchirawat S, Tangkijvanich P, Suksamrarn A, Limpachayaporn P. Synthesis of sorafenib analogues incorporating a 1,2,3-triazole ring and cytotoxicity towards hepatocellular carcinoma cell lines. Bioorg Chem. 2021 Mar 17;112:104831. doi: 10.1016/j.bioorg.2021.104831. Epub ahead of print. PMID: 33831675.
22. Teengam P, Siangproh W, Tontisirin S, Jiraseree-amornkun A, Chuaypen N, Tangkijvanich P, Henry CS, Ngamrojanavanich N, Chailapakul O. NFC-enabling smartphone-based portable amperometric immunosensor for hepatitis B virus detection. Sensors and Actuators B: Chemical. 2021 Jan;326:128825.
23. Srisomwat C, Yakoh A, Chuaypen N, Tangkijvanich P, Vilaivan T, Chailapakul O. Amplification-free DNA Sensor for the One-Step Detection of the Hepatitis B Virus Using an Automated Paper-Based Lateral Flow Electrochemical Device. Anal Chem. 2021 Feb 9;93(5):2879-2887. doi: 10.1021/acs.analchem.0c04283. Epub 2020 Dec 16. PMID: 33326737.
24. Srisomwat C, Teengam P, Chuaypen N, Tangkijvanich P, Vilaivan T, Chailapakul O. Pop-up paper electrochemical device for label-free hepatitis B virus DNA detection. Sensors and Actuators B: Chemical. 2020 Aug 1;316:128077.
25. Khlaiphuengsin A, Chuaypen N, Sodsai P, Reantragoon R, Han WM, Avihingsanon A, Tangkijvanich P. Successful direct-acting antiviral therapy improves circulating mucosal-associated invariant T cells in patients with chronic HCV infection. Plos one. 2020 Dec 31;15(12):e0244112.
26. Limothai U, Dinhuzen J, Payongsri T, Tachaboon S, Tangkijvanich P, Chuaypen N*, Srisawat N*. Circulating microtranscriptome profiles reveal distinct expression of microRNAs in severe leptospirosis. PLOS Neglected Tropical Diseases. 2020 Nov 11;14(11):e0008809. (IF=3.885, Tier1; *co-corresponding author)
27. Khlaiphuengsin A, Chuaypen N, Sodsai P, Buranapraditkun S, Boonpiyathad T, Hirankarn N, Tangkijvanich P. Decreased of BAFF-R expression and B cells maturation in patients with hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol. 2020 May 28
28. Pratedrat P, Chuaypen N, Nimsamer P, Payungporn S, Pinjaroen N, Sirichindakul B, Tangkijvanich P. Diagnostic and prognostic roles of circulating miRNA-223-3p in hepatitis B virus-related hepatocellular carcinoma. PLoS One. 2020 Apr 24
29. Limothai U, Chuaypen N, Poovorawan K, Chotiyaputta W, Tanwandee T, Poovorawan Y, Tangkijvanich P. Reverse transcriptase droplet digital PCR vs reverse transcriptase quantitative real-time PCR for serum HBV RNA quantification. J Med Virol 2020 Mar 26.
30. Limothai U, Chuaypen N, Poovorawan K, Chotiyaputta W, Tanwandee T, Poovorawan Y, Tangkijvanich P. Baseline and kinetics of serum hepatitis B virus RNA predict response to pegylated interferon-based therapy in patients with hepatitis B e antigen-negative chronic hepatitis B. Journal of viral hepatitis. 2019 Aug. (Q1, IF=4.016).
31. Limothai U, Chuaypen N, Poovorawan K, Poovorawan Y, Tangkijvanich P. Genetic variation in STAT4 is associated with treatment response to pegylated interferon in patients with chronic hepatitis B. Asian Pac J Allergy Immunol. 2019 Aug 18. doi: 10.12932/AP-020419-0533.
32. Chuaypen N, Posuwan N, Chittmittraprap S, Hirankarn N, Treeprasertsuk S, Tanaka Y, Shinkai N, Poovorawan Y, Tangkijvanich P. Predictive role of serum HBsAg and HBcrAg kinetics in patients with HBeAg-negative chronic hepatitis B receiving pegylated interferon-based therapy. Clin Microbiol Infect. 2018 Mar 1;24(3): 306.e7. (Tier 1, IF=5.394).
33. Raksayot M*, Chuaypen N*, Khlaiphuengsin A, Pinjaroen N, Treeprasertsuk S, Poovorawan Y, Tanaka Y, Tangkijvanich P. Independent and additive efffects of PNPLA3 and TM6SF2 polymorphisms on the development of non-B, non-C hepatocellular carcinoma. J Gastroenterol. 2019 May 1;54(5):427-36. *Equally distributed (Q1, IF=5.561).
34. Chuaypen N, Chittmittraprap S, Pinjaroen N, Sirichindakul B, Poovorawan Y, Tanaka Y, Tangkijvanich P. Serum WFA+‐M2BP Level as a Diagnostic Marker of Hepatitis B Virus‐related Hepatocellular Carcinoma. Hepatol Res 2018 May 6 (Q2, IF=3.415).
35. Chuaypen N, Payungporn S, Tangkijvanich P. Next generation sequencing identifies baseline HBV mutants associated with treatment response to pegylated interferon in patients with HBeAg-positive chronic hepatitis B. Virus Genes. DOI: 10.1007/s11262-019-01689-5. (Q2, IF=1.616)
36. Chuaypen N, Tuyapala N, Pinjaroen N, Payungporn S, Tangkijvanich P. Association of NTCP polymorphisms with clinical outcome of hepatitis B infection in Thai Individuals. BMC medical genetics. 2019 Dec;20(1):87 (Q3, IF=1.740).
37. Kiatbumrung R, Chuaypen N, Payungporn S, Avihingsanon A, Tangkijvanich P. The association of  PNPLA3, COX-2 and DHCR7 polymorphisms with advanced liver fibrosis in patients with HCV mono-infection and HCV/HIV co-infection. Asian Pac J Cancer Prev 2018.
38. Khlaiphuengsina A, Chuaypen N, Pinjaroen N, Sirichindakul B, Hirankarn N, Tangkijvanich P. Plasma B-cell activating factor levels and polymorphisms in hepatitis B-related hepatocellular carcinoma: Clinical correlation and prognosis. Asian Pac J Allergy Immunol. 2019.
39. Khlaiphuengsin A, Chuaypen N, Hirankarn N, Avihingsanon A, Crane M, Lewin SR, Tangkijvanich P. Circulating BAFF and CXCL10 levels predict response to pegylated interferon in patients with HBeAg-positive chronic hepatitis B. Asian Pac J Allergy Immunol. 2019.
40. Limothai U, Chuaypen N, Khlaiphuengsin A, Chittmittraprap S, Poovorawan Y, Tangkijvanich P. Association of vitamin-D-related genetic variations and treatment response to pegylated interferon in patients with chronic hepatitis B. Antivir Ther 2017; 22: 681-8.
41. Chuaypen N, Posuwan N, Payungporn S, Tanaka Y, Shinkai N, Poovorawan Y, et al. Serum hepatitis B core-related antigen as a treatment predictor of pegylated interferon in patients with HBeAg- positive chronic hepatitis B. Liver Int 2016; 36: 827-36. (Q1, IF=4.500)
42. Chuaypen N, Sriprapun M, Praianantathavorn K, Payungporn S, Wisedopas N, Poovorawan Y, et al. Kinetics of serum HBsAg and intrahepatic cccDNA during pegylated interferon therapy in patients with HBeAg-positive and HBeAg-negative chronic hepatitis B. J Med Virol 2017; 89:130-8. (Q2, IF=1.988).
43. Limothai U, Chuaypen N, Khlaiphuengsin A, Posuwan N, Wasitthankasem R, Poovorawan Y, et al. Association of interferon-gamma inducible protein 10 polymorphism with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B. Antivir Ther 2016;21:97-106.    
44. Tangkijvanich P, Chittmittraprap S, Poovorawan K, Limothai U, Khlaiphuengsin A, Chuaypen N, et al. A randomized clinical trial of peginterferon alpha-2b with or without entecavir in patients with HBeAg-negative chronic hepatitis B: Role of host and viral factors associated with treatment response. J Viral Hepat 2016;23:427-38.
45. Jinato T, Chuaypen N, Poomipak W, Praianantathavorn K, Makkoch J, Kiatbumrung R, et al. Analysis of hepatic microRNA alterations in response to hepatitis B virus infection and pegylated interferon alpha-2a treatment. Exp Biol Med (Maywood) 2016; 241: 1803-10.
46. Sriprapun M, Chuaypen N, Khlaiphuengsin A, Pinjaroen N, Payungporn S, Tangkijvanich P. Association of PINX1 but not TEP1 polymorphisms with progression to hepatocellular carcinoma in Thai patients with chronic hepatitis B virus Infection. Asian Pac J Cancer Prev 2016;17:2019-25.
47. Makkoch J, Praianantathavorn K, Sopipong W, Chuaypen N, Tangkijvanich P, Payungporn S. Genetic variations in XRCC4 (rs1805377) and ATF6 (rs2070150) are not associated with hepatocellular carcinoma in Thai patients with hepatitis B virus infection. Asian Pac J Cancer Prev 2016;17:591-5.
48. Chanthra N, Payungporn S, Chuaypen N, Pinjaroen N, Poovorawan Y, Tangkijvanich P. Association of single nucleotide polymorphism rs1053004 in signal transducer and activator of transcription 3 (STAT3) with susceptibility to hepatocellular carcinoma in Thai patients with chronic hepatitis B. Asian Pac J Cancer Prev 2015;16:5069-73.
49. Chanthra N, Payungporn S, Chuaypen N, Piratanantatavorn K, Pinjaroen N, Poovorawan Y, et al. Single nucleotide polymorphisms in STAT3 and STAT4 and risk of hepatocellular carcinoma in Thai patients with chronic hepatitis B. Asian Pac J Cancer Prev 2015;16:8405-10.
50. Chimparlee N, Chuaypen N, Khlaiphuengsin A, Pinjaroen N, Payungporn S, Poovorawan Y, et al. Diagnostic and prognostic roles of serum osteopontin and osteopontin promoter polymorphisms in hepatitis B-related hepatocellular carcinoma. Asian Pac J Cancer Prev 2015;16:7211-7.
51. Pratedrat P, Sopipong W, Makkoch J, Praianantathavorn K, Chuaypen N, Tangkijvanich P, et al. Single nucleotide polymorphisms in miR-149 (rs2292832) and miR-101-1 (rs7536540) are not associated with hepatocellular carcinoma in Thai patients with hepatitis B virus infection. Asian Pac J Cancer Prev 2015;16:6457-61.
52. Chuaypen N, Boonla C, Dissayabutra T, Predanon C, Ruangvejvorachai P, Waivijit U, Tosukhowong P. Increased intrarenal expression of sodium-dicarboxylate cotransporter-1 nephrolithiasis patients associates with acidic urine pH. Asian Biomedicine 2013; 7:571-7.